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Table 2 Standardized Incidence Ratios (SIRs) for subsequent primary sarcoma after any 1st cancer in adulthood according to radiotherapy and time since first cancer diagnosis, SEER 9 1973-2008

From: Sarcoma risk after radiation exposure

  Bone sarcoma Soft tissue sarcoma
Time since 1st Radiotherapy No radiotherapy Radiotherapy No radiotherapy
Cancer diagnosis Obs SIR Obs SIR Obs SIR Obs SIR
1-4 yrs 34 1.49* 77 1.32* 135 1.22* 311 1.15*
5-9 yrs 43 2.74* 56 1.24 185 2.22* 271 1.21*
10-14 yrs 23 3.23* 34 1.31 78 2.04* 141 1.06
15+ yrs 23 4.35* 24 0.94 62 2.20* 159 1.21*
Total 123 2.42* 191 1.23* 460 1.77* 882 1.16*
  1. *p < 0.05. Obs-observed number of subsequent primary sarcomas. Analysis includes adulthood (age 20–79 years at diagnosis) 1+ year survivors of any 1st cancer (excluding bone sarcoma or soft tissue sarcoma, respectively). Follow-up for second primary bone or soft tissue sarcoma continued to age 85 years. Patients with unknown radiotherapy were excluded.
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Clinical Sarcoma Research

ISSN: 2045-3329