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Table 3 Standardized Incidence Ratios for subsequent primary sarcoma after any 1st cancer in adulthood according to radiotherapy and age at 1st cancer diagnosis, SEER 9 1973-2008

From: Sarcoma risk after radiation exposure

  Bone sarcoma Soft tissue sarcoma
Age at 1st Radiotherapy No radiotherapy Radiotherapy No radiotherapy
Cancer diagnosis Obs SIR Obs SIR Obs SIR Obs SIR
20-39 yrs 13 4.40* 10 1.31 52 5.32* 58 2.25*
40-59 yrs 42 3.71* 40 1.23 129 2.41* 219 1.37*
60-79 yrs 40 2.60* 57 1.31 177 1.83* 302 1.15*
  1. *p < 0.05. Obs-observed number of subsequent primary sarcomas. SIR-standardized incidence ratio. Analysis includes adulthood (age 20–79 years at diagnosis) 1+ year survivors of any 1st cancer (excluding bone sarcoma or soft tissue sarcoma, respectively). Follow-up for second primary bone or soft tissue sarcoma continued to age 85 years. Patients with unknown radiotherapy were excluded.