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Table 4 Standardized Incidence Ratios for subsequent primary sarcoma according to type of first cancer and radiotherapy, SEER 9 1973-2008

From: Sarcoma risk after radiation exposure

  Bone sarcoma Soft tissue sarcoma
  Radiotherapy No radiotherapy Radiotherapy No radiotherapy
1st cancer type Obs SIR Obs SIR Obs SIR Obs SIR
Oral Cavity and Pharynx 9 7.61* 1 0.49 12 1.95* 8 0.75
Rectum and Anus 6 5.15* 6 1.77 12 1.82 18 0.96
Larynx 2 1.62 2 3.80 6 0.87 3 1.06
Lung and Bronchus 0 0.00 4 1.48 12 3.44* 19 1.30
Female Breast 21 2.59* 21 1.28 104 2.67* 101 1.29*
Cervix Uteri 6 6.62* 1 0.71 10 2.38* 6 1.04
Corpus Uteri 12 3.96* 3 0.62 27 1.89* 29 1.25
Ovary 3 13.99* 2 1.45 6 6.25* 9 1.44
Prostate 8 1.09 19 1.38 89 1.69* 97 1.05
Testis 0 0.00 0 0.00 9 2.60* 8 2.78*
Brain and CNS 3 10.47* 0 0.00 4 3.66* 3 3.44
Thyroid 4 4.12* 2 0.91 11 2.63* 10 1.04
Hodgkin Lymphoma 3 4.28 3 6.37* 22 8.71* 7 3.72*
Non-Hodgkin Lymphoma 10 9.00 7 2.92* 11 1.96 17 1.36
Leukemia 1 17.60 5 3.09* 1 4.17 10 1.16
  1. *p < 0.05. Obs-observed number of subsequent primary sarcomas. SIR-standardized incidence ratio. Analysis includes adulthood (age 20–79 years at diagnosis) 1+ year survivors of the specified 1st cancer type. Follow-up for second primary bone or soft tissue sarcoma continued to age 85 years. Patients with unknown radiotherapy were excluded.