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Table 1 In vitro cytotoxicity (IC50 values) of histone deacetylase inhibitors to chemo-sensitive and -resistant EWS cell linesa

From: Histone deacetylase inhibitors enhance expression of NKG2D ligands in Ewing sarcoma and sensitize for natural killer cell-mediated cytolysis

cell line NaB (mM) SAHA (μM) MS-275 (μM)
chemo-sensitive    
SK-ES-1 1.43 2.85 3.72
TC71 7.85 2.96 30.71
chemo-resistant    
CADO-ES 38.99 3.92 49.97
STA-ET2.1 0.61 1.58 10.06
  1. a 'natural' sensitivity of specific cell lines to chemotherapeutic drugs, as previously described [27, 35].
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Clinical Sarcoma Research

ISSN: 2045-3329